Steroid hormone mediated regulation of corticotropin-releasing hormone gene expression

Title: Steroid hormone mediated regulation of corticotropin-releasing hormone gene expression
Creator: Ni, Xin; Nicholson, Richard C.
Relation: Frontiers in Bioscience Vol. 11, p. 2909-2917
Publisher Link: http://dx.doi.org/10.2741/2019
Publisher: Frontiers in Bioscience
Resource Type: journal article
Date: 2006
Description: Corticotropin-releasing hormone (CRH), a 41 amino acid polypeptide, is expressed in many regions of central nervous system and peripheral tissues and mediates many physiological functions. Abnormal production of CRH is involved in some pathological processes. Among various endogenous factors that modulate CRH production, steroid hormones control CRH production by regulating its gene transcription. Although there is no classical steroid hormone response element in the CRH promoter, steroid hormones regulate CRH gene expression through protein-protein interaction or by binding directly to response elements.
Subject: corticotropin-releasing hormone; central nervous system; CRH production; gene transcription; steroid hormones
Identifier: http://hdl.handle.net/1959.13/33312
Identifier: uon:3173
Identifier: ISSN:1093-9946
Language: eng
Reviewed

		Thumbnail	File	Description	Size	Format